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  涂圣贤

  188BET金宝搏官网特聘教授，博士生导师，188BET金宝搏官网生物医疗仪器纵主任，生物医学仪器研究所心血管创新器械与智能计算实验室主任，188BET金宝搏官网-博动医学影像技术联合实验室主任，荷兰Erasmus大学医学院客座教授，国家心血管病影像专业委员会常务委员。主要从事心血管成像及生理功能学评估技术的研发与临床应用研究。2012年2月获得荷兰莱顿大学优秀博士学位，2014年回国加入188BET金宝搏官网陈亚珠院士研究团队，创建心血管影像研究方向。他发明了QFR、OFR、UFR与RWS等序列计算冠脉功能学评估技术，并主持完成这些技术的产学研与临床转化。近5年以第一作者或通讯作者（含共同）在Lancet, Nature Review Cardiology, JACC, European Heart Journal等国际知名期刊发表多篇论文。主持的项目“Real-time comprehensive assessment of coronary physiology and biomechanics from a single angiographic projection”获得2022年EuroPCR大会评选的心血管器械最佳创新奖与Jon DeHaan基金会奖金，成为该奖项设立以来首个获得殊荣的来自亚洲的项目。获得教育部长江学者特聘教授、上海市技术发明奖一等奖（第1完成人）、教育部科学研究优秀成果奖一等奖（第2完成人）等荣誉称号。

  
  

  实验室网页：https://ciiic.sjtu.edu.cn/

  
  

1. 国家自然科学基金委重大科研仪器研制项目，项目名称：血管内多模态成像与生物力学分析融合系统的研制；项目编号：82327808；时间：2024/1-2028/12。主持。

2. 国家自然科学基金重点国际合作项目，项目名称：影响冠心病患者生物可降解支架疗效的关键生物力学问题研究；项目编号：82020108015；时间：2021/1-2025/12。主持。

3. 国家自然科学基金面上项目，项目名称：冠心病患者非靶病变快速进展与斑块破裂的生物力学机制研究；项目编号：81871460；时间：2019/1-2022/12。主持。

4. 国家自然科学基金面上项目，项目名称：结合计算流体力学与三维光学相干断层成像评价冠心病支架治疗后的局部血流动力学；项目编号：81570456；时间：2016/1-2017/12。 主持。5. 国家自然科学基金青年科学基金项目，项目名称：基于冠状动脉CT血管造影评估血流储备分数与微循环阻力；项目编号：31500797；时间：2016/1-2018/12。主持。

6. 国家重点研发计划“科技助力经济2020”重点专项，项目名称：融合光学血流分数与虚拟组织学的一站式冠心病评估系统研发和应用示范；时间：2020/7-2022/6。主持。

7. 国家重点研发计划“数字诊疗装备研发重点专项”，项目名称：融合光学相干断层成像与血流动力学的一站式冠心病评估系统的研制；项目编号：2016YFC0100500；时间：2016/7-2018/12。主持。

1.   Chen Y#, Li G*, Li C, Yu W, Fan Z, Bai J, Tu S*. GVM-Net: A GNN-Based Vessel Matching Network for 2D/3D Non-Rigid Coronary Artery Registration. IEEE Transactions on Medical Imaging. 2025,44(6):2617-2630.

2.   Yang F#, Li C, Tan Q, Yu W, De Maria GL, Wang F, Wu J*, Tu S*. In Vivo Quantitative Imaging of Coronary Blood Flow by Intracoronary Doppler OCT. IEEE Transactions on Biomedical Engineering. 2025, 72(5): 1665-1673.

3.    Wang Z#, Kedhi E, Liu X, Li C, Huang J, Zhong J, Qu X*, Wijns W, Tu S*, Grp COFS. Prognostic Implications of Angiographically Derived Coronary Radial Wall Strain in Diabetic Patients and Non-Flow-Limiting Stenosis. JACC: Cardiovascular Interventions. 2025, 18(10): 1232-1242.

4.    Li C#, Qiao Y, Yu W, Li Y, Chen Y, Fan Z, Wei R, Yang B, Wang Z, Lu X, Chen L, Collet C, Chu M*, Tu S*. AutoFOX: An automated cross-modal 3D fusion framework of coronary X-ray angiography and OCT. Medical Image Analysis. 2025, 101: 103432.

5.   Hwang HY#*, Ding D#, Kang J, Sun P, Sohn SH, Tu S*, Koo B-K. Association Between Angiography-Derived Murray Law–Based Quantitative Flow Ratio and 1-Year Coronary Artery Bypass Graft Patency. JACC: Cardiovascular Interventions. 2025,18(19):2326-2334.

6.   Ding D#, Zhang J#, Wu P, Wang Z, Shi H, Yu W, Hu X, Kang J, Hahn J-Y, Nam C-W, Doh J-H, Lee B-K, Kim W, Huang J, Jiang F, Zhou H, Chen P, Tang L, Jiang W, Chen X, He W, Ahn SG, Yoon M-H, Kim U, Ki Y-J, Shin E-S, Tahk S-J, Pu J, Wijns W, Wang JA, Koo B-K*, Tu S*. Prognostic Value of Postpercutaneous Coronary Intervention Murray-Law-Based Quantitative Flow Ratio. JACC: Asia. 2025,5(1_Part_1):59-70.

7.    Li Z#, Tu S*, Matheson MB, Li G, Chen Y, Rochitte CE, Chen MY, Dewey M, Miller JM, R. Scarpa Matuck B, Yang W, Qin L, Yan F, Lima JaC, Arbab-Zadeh A, De Roos A, Wolfe S. Prognostic Value of Coronary CT Angiography–Derived Quantitative Flow Ratio in Suspected Coronary Artery Disease. Radiology. 2024,313(3):e240299.

8.   Chu M#, De Maria G*, Dai R, Benenati S, Yu W, Zhong J, Kotronias R, Walsh J, Andreaggi S, Zuccarelli V, Chai J, Oxford Acute Myocardial Infarction (OxAMI) Study, Channon K, Banning A, Tu S*. DCCAT: Dual-Coordinate Cross-Attention Transformer for thrombus segmentation on coronary OCT. Medical Image Analysis. 2024, 97: p103265.

9.  Fezzi S#, Ding D#, Mahfoud F, Huang J, Lansky AJ, Tu S*, Wijns W*. Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention? Nature Reviews Cardiology. 2024,21(9):652-662.

10.  Yang S#, Wang Z#, Park S, Hong H, Li C, Liu X, Chen L, Hwang D, Zhang J, Hoshino M, Yonetsu T, Shin E, Doh J, Nam C, Wang J, Chen S, Tanaka N, Matsuo H, Kubo T, Chang H, Kakuta T, Koo B*, Tu S*. Relationship of Coronary Angiography-Derived Radial Wall Strain With Functional Significance, Plaque Morphology, and Clinical Outcomes. JACC: Cardiovascular Interventions. 2024; 17(1): 46-56.

11.  Tu S#*, Xu B#*, Chen L, Hong H, Wang Z, Li C, Chu M, Song L, Guan C, Yu B, Jin Z, Fu G, Liu X, Yang J, Chen Y, Ge J, Qiao S, Wijns W, on behalf of the FAVOR III China study group. Short-term risk stratification of non–flow-limiting coronary stenosis by angiographically derived radial wall strain. Journal of the American College of Cardiology. 2023, 81(8):756–767.

12.  Li C#, Wang Z#, Yang H, Hong H, Li C, Xu R, Wu Y, Zhang F, Qian J, Chen L, Tu S*, Ge J*. The Association Between  ngiographically Derived Radial Wall Strain and the Risk of Acute Myocardial Infarction. JACC: Cardiovascular Interventions. 2023,16(9):1039-1049.

13.  Hong H#, Li C#, Gutiérrez-Chico JL, Wang Z, Huang J, Chu M, Kubo T, Chen L*, Wijns W, Tu S*.  Radial wall strain: a novel angiographic measure of plaque composition and vulnerability. EuroIntervention. 2022,18(12):1001-1010.

14.  Song L#, Xu B#, Tu S*, Guan C, Jin Z, Yu B, Fu G, Zhou Y, Wang J, Chen Y, Pu J, Chen L, Qu X, Yang J, Liu X, Guo L, Shen C, Zhang Y, Qi Zhang, Pan H, Zhang R, Liu J, Zhao Y, Wang Y, Dou K, Kirtane A, Wu Y, Wijns W, Yang W, Leon M, Qiao S*, Stone G, FAVOR III China Study Group. 2-Year Outcomes of Angiographic Quantitative Flow Ratio-Guided Coronary Interventions. Journal of the American College of Cardiology . 2022, 80(22):2089-2101.

15.  Hong H#, Jia H#, Zeng M, Gutiérrez-Chico JL, Wang Y, Zeng X, Qin Y, Zhao C, Chu M, Huang J, Liu L, Hu S, He L, Chen L, Wijns W, Yu B*, Tu S*. Risk Stratification in Acute Coronary Syndrome by Comprehensive Morphofunctional Assessment With Optical Coherence Tomography. JACC: Asia.2022, 4: 460-472.

16.  Xu B#*, Tu S#, Song L#, Jin Z, Yu B, Fu G, Zhou Y., Wang J. a, Chen Y, Pu J, Chen L, Qu X, Yang J, Liu X, Guo L, Shen C, Zhang Y, Zhang Q, Pan H, Fu X, Liu J, Zhao Y, Escaned J, Wang Y, Fearon W. F, Dou K, Kirtane A. J, Wu Y, Serruys P. W, Yang W, Wijns W, Guan C, Leon M. B, Qiao S, Stone G. W. Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial. The Lancet.2021, 398：2149-2159. 

17.  Ding D#, Huang J#, Westra J, Cohen D. J, Chen Y, Andersen B. K, Holm N. R, Xu B, Tu S*, Wijns W*. Immediate post-procedural functional assessment of percutaneous coronary intervention: current evidence and future directions. European Heart Journal. 2021,42:2695-2707.

18.  Chu M#, Jia H, Gutiérrez-Chico JL, Maehara A, Ali Z, Zeng Z, He L, Zhao C, Matsumura M, Wu P, Zeng M, Kubo T, Xu B, Chen L, Yu B, Mintz GS, Wijns W, Holm NR, Tu S*. Artificial intelligence and optical coherence tomography for the automatic characterisation of human atherosclerotic plaques.  EuroIntervention. 2021, 17:41-50. 

19.  Yu W#, Tanigaki T, Ding D, Wu P, Du H, Ling Li, Huang B, Li G, Yang W, Zhang S, Yan F, Okubo M, Xu B, Matsuo H, Wijns W, Tu S*. Accuracy of Intravascular Ultrasound-based Fractional Flow Reserve in Identifying Hemodynamic Significance of Coronary Stenosis. Circulation: Cardiovascular Interventions. 2021,4:e009840.

20.  Tu S#*, Ding D, Chang Y, Li C, Wijns W, Xu B. Diagnostic accuracy of quantitative flow ratio for assessment of coronary stenosis significance from a single angiographic view: A novel method based on bifurcation fractal law. Catheterization and Cardiovascular Interventions. 2021,97:1040-1047.

21.  Tu S#*, Westra J#, Adjedj J#, Ding D, Liang F, Xu B, Holm NR, Reiber H, Wijns W. Fractional Flow Reserve in clinical practice: from wire-based invasive measurement to image-based computation. European Heart Journal. 2020,41, 3271–3279.

22.   Yu W#, Huang H, Jia D, Chen S, Raffel OC, Ding D, Tian F, Kan J, Zhang S, Yan Y, Chen Y, Bezerra HG, Wijns W, Tu S*. Diagnostic Accuracy of Intracoronary Optical Coherence Tomography-derived Fractional Flow Reserve for Assessment of Coronary Stenosis Severity. EuroIntervention. 2019,15:189-197.

23.  Xu B#, Tu S#*, Qiao S, Qu X, Chen Y, Yang J, Guo L, Sun Z, Li Z, Tian F, Fang W, Chen J, Li W, Guan C, Holm NR, Wijns W, Hu S*. Diagnostic Accuracy of the Angiography-Based Quantitative Flow Ratio for Online Assessment of Coronary Stenosis. Journal of the American College of Cardiology. 2017, 70: 3077-3087.

24.  Tu S#*, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, Nef H, Tebaldi M, Murasato Y, Lansky A, Barbato E, van der Heijden LC, Reiber JHC, Holm NR, Wijns W,FAVOR Pilot Trial Study Group. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography: The International Multicenter FAVOR Pilot Study. JACC: Cardiovascular Interventions. 2016, 9:2024–35.

25.   Li Y#, Gutiérrez-Chico JL#, Holm NR, Yang W, Hebsgaard L, Christiansen EH, Mæng M, Lassen JF, Yan F, Reiber JHC, Tu S*. Impact of Side Branch Modeling on Computation of Endothelial Shear Stress in Coronary Artery Disease: Coronary Tree Reconstruction by Fusion of 3D Angiography and OCT. Journal of the American College of Cardiology. 2015, 66:125-35.

26.   Tu S#*, Barbato E, Koszegi Z, Yang J, Sun Z, Holm NR, Tar B, Li Y, Rusinaru D, Wijns W, Reiber JHC.Fractional flow reserve calculation from 3-dimensional quantitative coronary angiography and TIMIframe count: A fast computer model to quantify the functional significance of moderately obstructed coronary arteries. JACC: Cardiovascular Interventions. 2014, 7:768-777.